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Design robust RCT with appropriate statistical power. Study design: 1. Define primary outcome clearly (e.g., change in depression score). 2. Choose randomization method (simple, block, stratified). 3. Blinding strategy (single, double, triple-blind where possible). 4. Control group selection (placeb...
Maximize internal validity through experimental control. Threats to internal validity (Campbell & Stanley): 1. History: external events during study. Control: randomization, brief study duration. 2. Maturation: natural changes over time. Control: control group, random assignment. 3. Testing: effects...
