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Implement reactive programming with MobX. Concepts: 1. makeObservable or makeAutoObservable. 2. @observable for tracked properties. 3. @computed for derived values. 4. @action for state mutations. 5. observer() HOC for React. 6. reaction() for side effects. 7. runInAction for async updates. 8. Decorators or annotations. MobX automatically tracks dependencies. Use with TypeScript and strict mode for best practices.